PREDY-NT 75/10 Tablets
Pregabalin 75mg with Nortriptyline Hydrochloride 10mg Tablets
Reference MRP
₹199.00
Standard Packaging
10 Strips x 10 Film-Coated Tablets per carton (100 Tablets Box / Master Shipper: 60 Boxes)
PREDY-NT 75/10 Tablets deliver an intensified neuropathic pain management protocol for patients requiring higher pregabalin dosing. Manufactured under strict WHO-GMP Schedule M standards by Redition Pharma, this formulation pairs full-dose Pregabalin (75mg) with Nortriptyline Hydrochloride (10mg) for synergistic voltage-gated calcium channel modulation and descending noradrenergic inhibitory pathway enhancement. Ideal for step-up therapy from PREDY-NT 37.5/10 or as first-line treatment in moderate-to-severe neuropathic pain.
Lic. 12116801000249Request batch Certificate of Analysis (COA), technical dossier, and institutional rate contracts.
Pharmacological Advantages & Clinical Evidence
- 01
Full-Dose Pregabalin (75mg): Robust alpha-2-delta calcium channel modulation for moderate-to-severe neuropathic pain control.
- 02
Nortriptyline Hydrochloride (10mg): Reinforces descending noradrenergic inhibitory pain pathways and improves sleep architecture.
- 03
Step-Up Therapy Option: Ideal escalation from PREDY-NT 37.5/10 for patients with inadequate pain control at lower doses.
- 04
Authentic Batch Verification: Batch No. BC71477 with complete regulatory Certificate of Analysis (COA) compliance.
- 05
10 x 10 Tablets Packaging: Protected in moisture-barrier Alu-Alu blister foils inside UV-resistant clinical mono-carton.
Clinical Indications
- —Moderate-to-Severe Diabetic Peripheral Neuropathic Pain (DPNP)
- —Post-Herpetic Neuralgia (PHN)
- —Cervical & Lumbar Radiculopathy / Sciatica
- —Spinal Cord Injury Neuropathic Pain
- —Fibromyalgia & Chronic Central Pain Syndromes
- —Refractory Neuropathic Pain (Step-Up from Lower Dose)
Technical Specifications
- Active Ingredient
- Pregabalin, Nortriptyline Hydrochloride
- Dosage Form
- Film-Coated Tablet
- Pharmacopoeial Standard
- IP / In-House Validated Monograph
- Formulation Category
- Dual Alpha-2-Delta Ligand & Tricyclic Neuropathic Analgesic
- Administration
- As directed by the physician (Schedule H Prescription). Typically 1 tablet once or twice daily, swallowed whole with water. Do not crush or chew.
- Packaging Format
- 10 Strips x 10 Film-Coated Tablets per carton (100 Tablets Box / Master Shipper: 60 Boxes)
- Storage & Stability
- Store below 25°C in a dry place. Protect from direct sunlight and moisture. Keep out of reach of children. | Shelf life: 24 Months from manufacturing date
Mechanism of Action
Pregabalin 75mg provides potent binding to the alpha-2-delta auxiliary subunit of voltage-gated calcium channels in presynaptic neurons, substantially decreasing calcium influx and suppressing excitatory neurotransmitter release (glutamate, substance P, and CGRP). Nortriptyline simultaneously blocks norepinephrine and serotonin reuptake, reinforcing descending inhibitory control over dorsal horn nociceptive transmission for comprehensive pain modulation.
Institutional FAQs
How does PREDY-NT 75/10 differ from PREDY-NT 37.5/10?
PREDY-NT 75/10 contains double the Pregabalin dose (75mg vs 37.5mg) for patients requiring stronger neuropathic pain control. The Nortriptyline component remains 10mg in both strengths. It is prescribed as a step-up when the lower strength provides insufficient relief.
What is the MRP of PREDY-NT 75/10?
The MRP is ₹199.00 per strip of 10 tablets (inclusive of all taxes). Institutional and tender pricing is available on request.
Can PREDY-NT 75/10 be prescribed as first-line therapy?
Yes. In patients with moderate-to-severe neuropathic pain, physicians may initiate PREDY-NT 75/10 directly based on clinical severity, prior treatment history, and tolerability assessment.
Procurement & Dossier Request for PREDY-NT 75/10 Tablets
Submit your hospital tender requirements, rate-contract bids, or Certificate of Analysis (COA) requests. Our regulatory trade desk dispatches validated batch documentation within 24 hours.
Founder & Managing Director
Nilesh Kumar
Direct Sales & Dispatch Line
+91 79877 79819Regulatory Dossiers & RFQ
reditionpharma@gmail.comRegistered Corporate Office
101, 1st Floor, Bhumi Park Society, Punagam Chorasi Bombay Market, Surat, Gujarat 395010, India